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Research Related To Restore


Effectiveness of different cryotherapies on pain and disease activity in active rheumatoid arthritis. A randomized single-blinded controlled trial. - "Pain seemed to decrease more in patients in the whole-body cryotherapy at -110 degrees C than during other cryotherapies." 

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis - "The combined results suggest that a variable indoor environment with frequent cold exposures might be an acceptable and economic manner to increase energy expenditure and may contribute to counteracting the current obesity epidemic."

Cryotherapy in Treatment of Keloids: Evaluation of Factors Affecting Treatment Outcome - "Cryotherapy seems to be an effective treatment modality for keloids of recent onset, particularly smaller lesions".

Whole-body cryotherapy as adjunct treatment of depressive and anxiety disorders - “These findings, despite such limitations as a small sample size, suggest a possible role for WBCT as a short-term adjuvant treatment for mood and anxiety disorders.” 

The Influence of Temperature and Fibril Stability on Degradation of Cartilage Collagen by Rheumatoid Synovial Collagenase - "Part of the benefit from anti-inflammatory therapy in rheumatoid arthritis may be secondary to decreasing intra-articular temperatures, thereby decreasing the rate at which collagenase degrades cartilage collagen."

IV Drip Therapy

Intravenously administered vitamin C as cancer therapy: three cases - "We found 3 well-documented cases of advanced cancers, confirmed by histopathologic review, where patients had unexpectedly long survival times after receiving high-dose intravenous vitamin C therapy." 

Intravenous Micronutrient Therapy (Myers' Cocktail) for Fibromyalgia: A Placebo-Controlled Pilot Study - "At 8 weeks, the IVMT group experienced significantly improved tender points, pain, depression, and quality of life directly following treatment". 

Hyperbaric Oxygen Therapy

Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumatic Brain Injury - Randomized Prospective Trial - "In conclusion, this study provides, for the first time, convincing results based on a crossover study, demonstrating that HBOT can induce neuroplasticity and significant brain function improvements in mild TBI patients with prolonged Post-Concussion-Syndrome at late chronic stage, years after injury." 

Suppressive effect of hyperbaric oxygenation on immune responses of normal and autoimmune mice. - "Furthermore, long term HBO exposure results in the suppression of the development of autoimmune symptoms such as proteinuria, facial erythema and lymphadenopathy in MRL/lpr mice. All these results suggest that HBO is applicable for the treatment of autoimmune diseases."

Hyperbaric oxygen treatment attenuates the pro-inflammatory and immune responses in apolipoprotein E knockout mice - "Furthermore, HBO treatment results in a profound attenuation in the production of pro-inflammatory cytokines in response to an inflammatory stimulus (LPS), which is accompanied by a marked increase in the constitutive production of the anti-inflammatory cytokine."

Hyperbaric oxygen and wound healing - "With the increase in availability of chambers across the country, and with increasing number of studies proving the benefits of adjunctive use for various kinds of wounds and other indications, HBOT should be considered in these situations as an essential part of the overall management strategy for the treating surgeon."

Hyperbaric oxygen as an adjunctive therapy in treatment of malignancies, including brain tumours - "We conclude that the administration of HBO can provide many clinical benefits in the treatment of tumours, including management of highly malignant gliomas."

Effects of oxygen enrichment of room air on sleep patterns at high altitude - "Installing an oxygen-enriched room at high altitude is relatively simple and inexpensive, and there will be a promise for improving sleep quality, well-being, and work capacity."


Sauna Use Associated with Reduced Risk of Cardiac, All-Cause Mortality - “This study provides prospective evidence that sauna bathing is a protective factor against the risk of SCD, fatal CHD, fatal CVD, and all-cause mortality events in the general male population.”

Effect of hyperthermia and physical activity on circulating growth hormone - “Both exercise and heat exposure, separately, are sufficient to increase significantly the plasma GH concentration, and their combined effect induced a highly synergistic rise in GH.”

Heat acclimation responses of an ultra-endurance running group preparing for hot desert-based competition - “Heat acclimation induces adaptations that improve exercise tolerance in hot conditions.”

The sauna, skin and skin diseases - “Sauna bathing facilitates the removal of hyperkeratotic scales in psoriasis, and the use of petrolatum, emollient creams or topical antipsoriatic regimens has been found to be beneficial for many patients. Dermatophytes and other infective microorganisms are easily killed by the heat of the sauna.”

Changes in mood state following whole-body hyperthermia - “Mood states of cancer patients were assessed pre- and post-41.8 degrees C whole-body hyperthermia using the Profile of Mood States questionnaire. … a significant improvement in depression was evident through 72 h following treatment.” 


Compression Therapy

Dynamic Compression Enhances Pressure-to-Pain Threshold in Elite Athlete Recovery: Exploratory Study - "We conclude that PPDC (peristaltic pulse dynamic compression) is a promising means of accelerating and enhancing recovery after the normal aggressive training that occurs in Olympic and aspiring Olympic athletes."

Peristaltic pulse dynamic compression of the lower extremity enhances flexibility - “PPDC provides a means of rapidly enhancing acute ROM requiring less discomfort and time.” 

Peripheral conduit and resistance artery function are improved following a single, 1-h bout of peristaltic pulse external pneumatic compression - "Acutely, whole limb, lower pressure EPC improves conduit artery endothelial function systemically, but only improves RH blood flow locally (i.e., compressed limbs)."


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